[1]曹炳华,乔振虎.缺血性脑卒中患者血清SIRT1水平与早期神经功能恶化的相关性研究[J].卒中与神经疾病杂志,2022,29(04):330-332,348.[doi:10.3969/j.issn.1007-0478.2022.04.005]
　Cao Binghua,Qiao Zhenhu..Correlation between serum SIRT1 and early neurological deterioration of patients with ischemic stroke[J].Stroke and Nervous Diseases,2022,29(04):330-332,348.[doi:10.3969/j.issn.1007-0478.2022.04.005]
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缺血性脑卒中患者血清SIRT1水平与早期神经功能恶化的相关性研究()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第29卷
期数:
2022年04期
页码:
330-332,348
栏目:
论著
出版日期:
2022-09-10

文章信息/Info

Title:
Correlation between serum SIRT1 and early neurological deterioration of patients with ischemic stroke
文章编号:
1007-0478(2022)04-0330-04
作者:
曹炳华; 乔振虎
530001 南宁,广西壮族自治区民族医院神经内科二区[曹炳华 乔振虎(通信作者)]
Author(s):
Cao Binghua;  Qiao Zhenhu.
Department of Neurology, National Hospital of Guangxi Zhuang Autonomous Region, Guangxi Medical University, Nanning 530001
关键词:
缺血性脑卒中; SIRT1; 早期神经功能恶化; 相关性
Keywords:
Ischemic stroke SIRT1 Early neurological deterioration Correlation
分类号:
R743.3
DOI:
10.3969/j.issn.1007-0478.2022.04.005
文献标志码:
A
摘要:
目的 探讨缺血性脑卒中患者血清沉默信息调节因子1(Silent information regulator 1,SIRT1)水平与早期神经功能恶化(Early neurological deterioration,END)的相关性。方法 选取2020年1月-2021年6月于本院就诊的缺血性脑卒中患者136例,根据患者入院72 h内是否出现END,将其分为合并END组(41例)和非END组(95例),检测并比较2组血清SIRT1水平,采用Logistic回归法分析END发生的影响因素,采用受试者工作特征曲线(Receiver operating characteristic curve,ROC)分析SIRT1诊断END发生的临床价值。结果 2组患者年龄、糖尿病占比、冠心病占比、基线美国国立卫生院卒中量表(National institute of health stroke scale,NIHSS)评分比较差异显著(P<0.05); 与非END组比较,合并END组患者血清SIRT1水平较低,超敏C反应蛋白(High sensitivity C-reactive protein,hs-CRP)水平较高(P<0.05); 糖尿病史、年龄、hs-CRP水平及SIRT1水平是缺血性脑卒中患者发生END的独立危险因素(P<0.05); SIRT1预测缺血性脑卒中患者发生END的曲线下面积为0.753[95%CI=0.559～0.903,P<0.05],诊断特异度为81.49%,敏感度为89.15%。结论 SIRT1在缺血性脑卒中早期神经功能恶化患者血清中呈低表达,且其表达水平与缺血性脑卒中患者发生END有关。
Abstract:
ObjectiveTo explore the relationship between serum silent information regulator 1(SIRT1)and early neurological deterioration(END)of patients with ischemic stroke.Methods The clinical data of 136 patients with ischemic stroke who were treated in our hospital from January 2020 to June 2021 were retrospectively analyzed. According to whether patients had END within 72 hours of admission, they were divided into combined END group(41 cases)and non-END group(95 cases).The serum SIRT1 in these two groups were detected, and the logistic regression method was used to analyze the independent risk factors of END. A receiver operating characteristic(ROC)curve was applied to analyze the predictive value of SIRT1 for the diagnosis of END in patients with ischemic stroke.Results There were significant differences in age, proportion of diabetes, proportion of coronary heart disease, and baseline of National Institute of Health Stroke Scale(NIHSS)scores between the combined END group and non-END group(P<0.05).Compared with the non-END group, serum SIRT1 was lower and high sensitivity C-reactive protein(hs-CRP)was higher in patients with ischemic stroke in the combined END group(P<0.05).The history of diabetes, age, serum hs-CRP and SIRT1 were independent risk factors for END in patients with ischemic stroke(P<0.05).The area under the curve(AUC)of SIRT1 was 0.753(95%CI=0.559～0.903, P<0.05)for predicting the occurrence of END in patients with ischemic stroke. The specificity for diagnosis was 81.49%, and the sensitivity was 89.15%.Conclusion The serum SIRT1 is low in the END patients with ischemic stroke, which is related to the occurrence of END.

参考文献/References:

[1] Gwak DS, Kwon JA, Shim DH, et al. Perfusion and diffusion variables predict early neurological deterioration in minor stroke and large vessel occlusion[J]. J Stroke, 2021, 23(1): 61-68.
[2] 田园,王南南.血清25羟维生素D_3水平与急性脑梗死早期神经功能恶化的相关性分析[J].脑与神经疾病杂志,2020,28(9):36-40.
[3] 庄莉,丁秀和,闫燕,等.血清沉默信息调节因子1(SIRT1)和Nephrin与糖尿病肾损害的相关性研究[J].吉林医学,2019,40(12):2751-2754.
[4] Zhang M, Zhu W, Ma Y, et al. Early neurological deterioration and hypoperfusion volume ratio on arterial spin labeling in patients with acute ischemic stroke[J]. J Stroke Cerebrovasc Dis, 2021, 30(8): 105885.
[5] 王文家,娄淑杰.SIRT1对阿尔茨海默病氧化应激的调控和机制[J].中国细胞生物学学报,2020,42(11):2038-2044.
[6] 中华医学会神经病学分会.中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2018[J].中华神经科杂志,2018,51(9):666-682.
[7] 李娜,吴芬香,李涛,等.老年急性缺血性脑卒中患者静脉溶栓后早期神经功能恶化的相关因素分析[J].中华老年医学杂志,2021,40(8):1005-1009.
[8] 秦雪娇,滕振杰,孙强,等.缺血性卒中患者血管周围间隙扩大与脑小血管病影像学标志物的相关性[J].中华行为医学与脑科学杂志,2021,30(8):701-707.
[9] [nam KW. Kwon H M,lee Y S.abstract P665:different predictive factors for early neurological deterioration based on the location of single subcortical infarction[J]. Stroke, 2021, 52(Suppl_1): 587-589.
[10] Zhan Y, Yang C, Zhang Q, et al. Silent information regulator type-1 mediates amelioration of inflammatory response and oxidative stress in lipopolysaccharide-induced acute respiratory distress syndrome[J]. J Biochem, 2021, 169(5): 613-620.
[11] Sui M, Chen G, Mao X, et al. Gegen qinlian decoction ameliorates hepatic insulin resistance by silent information regulator1(SIRT1)-Dependent deacetylation of forkhead box O1(FOXO1)[J]. Med Sci Monit, 2019, 25(11): 8544-8553.
[12] Singh V, Ubaid S. Role of silent information regulator 1(SIRT1)in regulating oxidative stress and inflammation[J]. Inflammation, 2020, 43(5): 1589-1598.
[13] 邱珍,夏中元.沉默信息调节剂1对心肌缺血/再灌注损伤保护作用的研究进展[J].国际麻醉学与复苏杂志,2019,40(2):180-184.
[14] Sun XJ, Zhao X, Xie JN, et al. Crocin alleviates schizophrenia-like symptoms in rats by upregulating silent information regulator-1 and brain derived neurotrophic factor[J]. Compr Psychiatry, 2020, 103(103): 152209.
[15] 李贵美,徐平.沉默信息调节因子1在认知功能障碍中的研究进展[J].神经损伤与功能重建,2020,15(9):519-521, 527.

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备注/Memo

备注/Memo:
基金项目:广西中医药民族医药自筹经费科研课题(GZZC16-41); 崇左市科技计划项目合同(崇科攻2019004)
更新日期/Last Update: 2022-09-10