[1]徐美荣,吴甘霖.不同病情严重程度阿尔茨海默病患者血清IL-33,Il-1β的水平变化及其临床意义[J].卒中与神经疾病杂志,2022,29(05):466-469,474.[doi:10.3969/j.issn.1007-0478.2022.05.014]
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不同病情严重程度阿尔茨海默病患者血清IL-33,Il-1β的水平变化及其临床意义()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第29卷
期数:
2022年05期
页码:
466-469,474
栏目:
论著
出版日期:
2022-10-10

文章信息/Info

文章编号:
1007-0478(2022)05-0466-05
作者:
徐美荣吴甘霖
437100 湖北科技学院附属第二医院老年科(徐美荣); 湖北科技学院医学部全科医学实验教学示范中心[吴甘霖(通信作者)]
关键词:
白细胞介素-33白细胞介素-1β阿尔茨海默病
分类号:
R742
DOI:
10.3969/j.issn.1007-0478.2022.05.014
文献标志码:
A
摘要:
目的 探讨不同病情严重程度阿尔茨海默病(Alzheimer's disease,AD)患者血清白介素-33(Interleukin-33,IL-33)、白介素-1β(Interleukin-1β,Il-1β)的水平变化及其临床意义。方法 选取60例阿尔茨海默病住院患者(AD组)和40例健康老年者(N组)作为研究对象,进行回顾性病例-对照研究; 采用简易精神状态量表(Mini-mental state examination,MMSE)评价标准将AD组分为轻度组、中度组、重度组; 用酶联免疫吸附测定(Enzyme linked immunosorbent assay,ELISA)法检测患者血清IL-33和IL-1β水平。结果 与N组比较,轻度组IL-1β水平升高(P<0.05),IL-33水平降低,但无明显差异(P>0.05); 随病情加重,IL-33水平呈降低趋势,IL-1β水平呈升高趋势(P<0.05)。回归分析显示,IL-33水平与AD的严重程度呈独立负相关(P<0.001); Il-1β水平与AD的发生风险和AD的严重程度呈独立正相关(P<0.001)。采用受试者工作特征曲线(Receiver operating characteristic curve,ROC)分析显示IL-33的曲线下面积(Area Under Curve,AUC)是0.807,敏感性和特异性最好的截断值是30 ng/L(P<0.01); IL-1β的AUC是0.913,敏感性和特异性最好的截断值是1.77 ng/L(P<0.01)。结论 在体内IL-33和IL-1β水平异常变化可能是导致AD发生或程度加重的危险因素之一; 对于已经发生AD的患者,IL-33和IL-1β水平均可以作为评估病情严重程度的指标。

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:湖北省教育厅科学研究计划项目(B2021227)
更新日期/Last Update: 2022-10-10