[1]强毅娜 高杰. 富亮氨酸胶质瘤失活1蛋白抗体阳性相关免疫脑炎1例临床分析并文献复习[J].卒中与神经疾病杂志,2016,23(03):174-176.[doi:10.3969/j.issn.1007-0478.2016.03.008]
　Qiang Yina,Gao Jie.. Clinical analysis of 1 patient with leucine-rich glioma inactivated-1 protein antibody positive limbic encephalitis:A case report and review of literature[J].Stroke and Nervous Diseases,2016,23(03):174-176.[doi:10.3969/j.issn.1007-0478.2016.03.008]
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 富亮氨酸胶质瘤失活1蛋白抗体阳性相关免疫脑炎1例临床分析并文献复习(/HTML)
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第23卷
期数:
2016年03期
页码:
174-176
栏目:
论 著
出版日期:
2016-06-24

文章信息/Info

Title:
 Clinical analysis of 1 patient with leucine-rich glioma inactivated-1 protein antibody positive limbic encephalitis:A case report and review of literature
作者:
 强毅娜 高杰
 作者单位: 710043 西安,陕西省第四人民医院神经内科(强毅娜); 第四军医大学西京医院神经内科(高杰)
Author(s):
 Qiang Yina;  Gao Jie.
 Department of Neurology,the Fourth People’s Hospital of Shaanxi, Xi’an 710043
关键词:
 ; 富亮氨酸胶质瘤失活1蛋白 脑炎 颞叶癫痫间免疫球蛋白 糖皮质激素
Keywords:
 ;  LGI1 Encephalitis Temporal lobe epilepsy Immunoglobulin Glucocorticoids
分类号:
R743
DOI:
10.3969/j.issn.1007-0478.2016.03.008
文献标志码:
A
摘要:
 目的 报道富亮氨酸胶质瘤失活1蛋白(LGI1)自身抗体阳性免疫脑炎1例,结合文献分析,以提高临床医师对该病的认识。方法 结合文献分析该LGI1抗体阳性相关免疫脑炎患者的临床资料,并分析疗效。结果 中年男性急性起病,以肢体麻木、意识丧失、精神症状、癫痫间发作、四肢不自主运动为主要临床表现并伴低钠血症。脑脊液细胞、生化、免疫均正常,肿瘤相关抗原未见异常,副肿瘤抗体阴性,影像学检查排除颅内肿瘤。脑电图检查示右侧额颞导多量阵发性慢波异常及棘慢综合波。双侧海马区冠状位FLAIR序列提示双侧高信号,血清及脑脊液LGI-1抗体均(++)。结论 LGI1自身抗体阳性免疫脑炎以颞叶癫痫间作、精神异常为主要临床表现,常伴有低钠血症,病灶累及颞叶内侧为主,海马冠状位FLAIR序列常为高信号,免疫调节治疗及大剂量激素效果显著。
Abstract:
ObjectiveTo report one cases of leucine-rich glioma inactivated-1 protein antibody associated with limbic encephalitis,improving the clinical recognition of the disease.Methods We analyzed the clinical data and summarized curative effect combined with literature.Results Acute onset,middle-aged men with numbness,loss of consciousness,mental symptoms,seizures,limb involuntary movement as the main clinical manifestations and with hyponatremia.CSF biochemical,immune cells are normal and tumor related antigen did not see unusual,paraneoplastic antibody is negative,imaging exclusion of intracranial tumor. EEG show slow waves or epileptic form discharge. The flair MRI scans mainly show high signals in the medial temporal lobe. Blood and CSF LGI-1 antibodies is positive(++).Conclusion Anti-LGI1 encephalitis often show temporal lobe epilepsy,mental disorders as the main clinical manifestations accompanied by hyponatremia. The flair MRI scans mainly show high signals in the medial temporal lobe,immune regulation and high dose hormone treatment isremarkable.

参考文献/References:

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备注/Memo

备注/Memo:
 (2015-09-23收稿 2015-11-19修回)
更新日期/Last Update: 2016-06-24