[1]张勇 卢祖能 董红娟等. 帕金森病非运动症状及其治疗的流行病学调查[J].卒中与神经疾病杂志,2016,23(05):343-346.[doi:10.3969/j.issn.1007-0478.2016.05.010]
　Zhang Yong,Lu Zuneng,Dong Hongjuan,et al. An epidemiological study about prevalence and therapy of non-motor symptoms in Parkinson’s disease[J].Stroke and Nervous Diseases,2016,23(05):343-346.[doi:10.3969/j.issn.1007-0478.2016.05.010]
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第23卷
期数:
2016年05期
页码:
343-346
栏目:
论 著
出版日期:
2016-10-26

文章信息/Info

Title:
 An epidemiological study about prevalence and therapy of non-motor symptoms in Parkinson’s disease
作者:
 张勇 卢祖能 董红娟等
 430060 武汉大学人民医院神经内科[张勇 卢祖能(通信作者)董红娟 张红 黄婷婷 罗璨]
Author(s):
 Zhang Yong;  Lu Zuneng;  Dong Hongjuan;  et al.
 Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060
关键词:
 ; 帕金森病 非运动症状 治疗 日常生活质量
Keywords:
Parkinson’s disease Non-motor symptoms Therapy Quality of life
分类号:
R742.5
DOI:
10.3969/j.issn.1007-0478.2016.05.010
文献标志码:
A
摘要:
 目的 调查帕金森病(Parkinson’s Disease, PD)非运动症状(Non-motor symptom, NMS)的发生率、严重程度、持续时间、治疗情况及其对生活质量的影响。方法 2014年1月～2016年4月对139例PD患者和87例健康成人(对照组)运用非运动症状评分(Non-Motor Symptoms Scale,NMSS)调查NMS,运用帕金森病生活质量问卷39项(39-item Parkinson’s Disease Questionnaire,PDQ-39)评估生活质量,运用Hoehn& Yahr(H-Y)分级评定PD患者运动症状的严重程度,并记录研究对象的一般情况和治疗情况,分析PD患者生活质量的影响因素。结果 98.6%的PD患者存在NMS,平均NMSS总分[(61.46±41.92),(0～208)]。在PD患者中发生率超过50%的NMS依次如下:夜尿、便秘、不宁腿、性欲下降、性功能障碍、失眠、乏力; 平均NMSS≥3分的NMS依次如下:便秘、性欲下降、性功能障碍、乏力、失眠、不宁腿、尿频、夜尿; 平均持续时间≥2年的NMS依次如下:便秘、性欲改变、夜尿、勃起障碍、快速动眼睡眠行为异常(REM Sleep Behavior Disorder Questionnaire,RBD)、嗅觉障碍。PD患者中通便药、安眠药、抗抑郁药和排尿困难药的使用率分别为47.8%(43/90)、19.7%(13/66)、2.7%(2/74)、2.6%(2/76)。PD患者中通便药使用率显著多于正常人群(P<0.0001),2组安眠药使用率比较无明显差异(P=0.736),对照组无人使用改善情绪和排尿困难的药物。多重线性回归分析发现,调查时年龄、H-Y分级和NMS总分是PD患者日常生活质量的预测因素。结论 NMS几乎见于每例PD患者,自主神经功能紊乱、嗅觉障碍和RBD等NMS可用于辅助PD早期诊断,NMS降低PD患者的生活质量,需要加强对NMS的关注。
Abstract:
  ObjectiveTo investigate the prevalence, severity, duration and therapy of non-motor symptoms(NMS)in Parkinson’s disease(PD)and the impact of NMS on quality of life in PD patients.Methods The non-motor symptoms scale(NMSS)was administrated to 139 patients with PD and 87 healthy adults between January 2014 and April 2016. We investigated demographic characteristics, quality of life and managements and compared the clinical characteristics and quality of life between the two groups.Results There were 98.6% NMS in PD patients. The mean total NMSS score in PD patients was 61.46±41.92 with a range from 0 to 208. The more common NMS included nocturia, constipation, restless legs, altered interest in sex, problems having sex, insomnia and fatigue. The more severe NMS included constipation, altered interest in sex, problems having sex, fatigue, insomnia, restless legs, frequency and nocturia. The longer NMS included constipation, altered interest in sex, nocturia, problems having sex, REM sleep behavior disorder and hyposmia. The use ratio of purgatives, hypnotics, antidepressants and drugs to treat dysuria were 47.8%, 19.7%, 2.7% and 2.6%. Age on convey, H-Y stage and NMSS score were the strongest predictors for PDQ-39 scores in PD patients(P<0.05).Conclusion NMS is very common in PD patients. Some NMS can contribute to the early diagnosis of PD and decrease the quality of life of PD patients. It is necessary to pay great attention to NMS.

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备注/Memo

备注/Memo:
 (2016-06-08收稿)
更新日期/Last Update: 2016-10-30