[1]罗高权 杨路 梁磊等.添加维生素D3治疗50例缓解复发型多发性硬化的研究[J].卒中与神经疾病杂志,2016,23(04):245-247.[doi:10.3969/j.issn.1007-0478.2016.04.007]
 Luo Gaoquan,Yang Lu,Liang Lei,et al. Supplement of vitamin D3clinical in treatment of 50 cases of relapsing remitting multiple sclerosis [J].Stroke and Nervous Diseases,2016,23(04):245-247.[doi:10.3969/j.issn.1007-0478.2016.04.007]
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添加维生素D3治疗50例缓解复发型多发性硬化的研究
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第23卷
期数:
2016年04期
页码:
245-247
栏目:
论 著
出版日期:
2016-08-26

文章信息/Info

Title:
 Supplement of vitamin D3clinical in treatment of 50 cases of relapsing remitting multiple sclerosis 
作者:
 罗高权 杨路 梁磊等
:510010 广州军区广州总医院神经内科(罗高权 黎春镛 陈状 公方和),药剂科(梁磊); 南方医科大学中西医结合医院康复科(杨路)
Author(s):
 Luo Gaoquan Yang Lu Liang Leiet al.
 Department of Neurology, Guangzhou Army General Hospital,Guangzhou 510010
关键词:
 维生素D3 多发性硬化 T细胞亚群 激素
Keywords:
 Vitamin D3 Multiple sclerosis T lymphocyte subsets Hormone
分类号:
R744.5
DOI:
10.3969/j.issn.1007-0478.2016.04.007
文献标志码:
A
摘要:
 目的 探讨维生素D3添加治疗缓解复发型多发性硬化(RRMS)患者的临床疗效和安全性。方法 将50例缓解复发型多发性硬化(RRMS)患者随机分成维生素D3组和激素组,每组各25例,维生素D3组在激素治疗的基础上添加骨化三醇胶丸口服,治疗前后检测外周血T细胞亚群CD4+、CD8+、CD4+/ CD8+、Th1、Th2数量,评定NIHSS分值,观察并记录治疗期间药物的安全性及副作用。结果 治疗前维生素D3组与激素组在年龄、病程、性别以及NIHSS评分比较差异无统计学意义(<i>P</i>&gt;0.05),治疗后CD8+、CD4+/ CD8+、Th2数与治疗前比较及治疗后2组间比较差异均无统计学意义(<i>P</i>&gt;0.05),治疗后CD4+、Th1数、NIHSS评分与治疗前比较及治疗后2组间比较差异有统计学意义(<i>P</i>&lt;0.05)。结论 维生素D3添加治疗缓解复发型多发性硬化(RRMS)患者具有较好的临床疗效。
Abstract:
 ObjectiveTo study the clinical efficacy and safety of vitamin D3 in patients with relapsing remitting multiple sclerosis(RRMS)by using clinical randomized controlled study.Methods 50 cases of relapsing remitting multiple sclerosis in patients with relief, were randomly divided into vitamin D3 group and prednisone group, 25 cases in each group, vitamin D3 group in the treatment of hormone based add calcitriol capsules. The lymphocyte subsets, CD8+, CD8+ T, Th1, CD4+/, CD4+, Th2, NIHSS scores were detected, and the safety and side effects of the drugs during the treatment were evaluated.Results There was no significant difference between the treatment of vitamin D3 group and the hormone group in age, duration of disease, gender and NIHSS numerical(<i>P</i>&gt;0.05), there was no significant difference between before treatment and after treatment in CD8 + and CD4 CD8 + cells and Th2 numerical(<i>P</i>&gt;0.05), there was no significant difference between before treatment and after treatment in CD4 + Th1, NIHSS score(<i>P</i>&lt;0.05).Conclusion vitamin D3 has good clinical effect in the treatment of RRMS, and can be used in clinic.

参考文献/References:

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备注/Memo

备注/Memo:
(2015-10-09收稿)
 基金项目:广东省医学科学技术研究基金(项目编号为A2014487); 广东省公益研究与能力建设专项资金(项目编号为2014A020212259)
更新日期/Last Update: 2016-08-31