[1]黄廷富 何永利 潘小平. 急性脑梗死患者神经功能缺损与血清PON-1和ox-LDL水平的相关性研究[J].卒中与神经疾病杂志,2016,23(04):250-254.[doi:10.3969/j.issn.1007-0478.2016.04.009]
　Huang Tingfu,He Yongli,Pan Xiaoping.. Correlation analysis between neurological deficit and serum levels of PON-1 and ox-LDL in the patients of acute cerebral infarction [J].Stroke and Nervous Diseases,2016,23(04):250-254.[doi:10.3969/j.issn.1007-0478.2016.04.009]
点击复制

 急性脑梗死患者神经功能缺损与血清PON-1和ox-LDL水平的相关性研究
(/HTML)
分享到：

《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第23卷
期数:
2016年04期
页码:
250-254
栏目:
论 著
出版日期:
2016-08-26

文章信息/Info

Title:
 Correlation analysis between neurological deficit and serum levels of PON-1 and ox-LDL in the patients of acute cerebral infarction  
作者:
 黄廷富 何永利 潘小平
400060 重庆市职业病防治院 重庆市第六人民医院内三科[黄廷富 何永利(通信作者)],放射科(潘小平)
Author(s):
 Huang Tingfu; He Yongli; Pan Xiaoping.
 The Third Department of Internal Medicine,Chongqing Occupational Disease Prevention and Treatment Hospital,Chongqing 400060
关键词:
 ; 急性脑梗死 神经功能缺损 对氧磷酶-1 氧化型低密度脂蛋白
Keywords:
 ;  Acute cerebral infarction Neurological deficit Paraoxonase 1 Oxidized low density lipoprotein
分类号:
R
DOI:
10.3969/j.issn.1007-0478.2016.04.009
文献标志码:
A
摘要:
目的 检测急性脑梗死患者血清对氧磷酶-1( paraoxonase 1,PON-1)和氧化型低密度脂蛋白(oxidized low density lipoprotein,ox-LDL)水平,分析急性脑梗死患者神经功能缺损与血清PON-1和ox-LDL水平的相关性。方法 根据第四届全国脑血管病会议制订的诊断标准,选择符合条件的急性脑梗死患者78例、非脑梗死对照组52例。双抗体夹心ELISA法测定ox-LDL血清水平,采用乙酸苯酯法测定血清PON-1水平,所有急性脑梗死患者进行NIHSS评分和Glasgow昏迷评分。结果 与非脑梗死对照组比较,脑梗死患者在性别、平均年龄和Glasgow昏迷评分上没有统计学意义,在危险因子上具有显著差别,脑梗死患者ox-LDL 血清水平均显著高于对照组,PON-1血清水平均显著低于对照组。脑梗死患者NIHSS评分分数随着ox-LDL血清水平的增高而增加,随着PON-1血清水平的降低而增高。脑梗死患者Glasgow评分分数随着ox-LDL血清水平的增高而降低,随着PON-1血清水平的增高而增高。结论 在急性脑梗死患者中血清PON-1和ox-LDL水平和神经功能缺损有着密切的关系。ox-LDL血清水平的越高,神经功能缺损就越重,相反PON-1血清水平的越低,神经功能缺损就越重。
Abstract:
 ObjectiveTo analyse the relationship between neurological dysfunction in acute cerebral infarction and serum levels of PON-1 and ox-LDL,and evaluate the role of PON-1 and ox-LDL in the pathogenesis of acute cerebral infarction.Methods 78 cases of patients with acute cerebral infarction were collected according to the fourth Chinese national diagnostic criteria of cerebrovascular diseases.The subjects were divided into two groups:acute cerebral infarction group(78 cases),control group without acute cerebral infarction(52cases).Ox-LDL was measured by enzyme linked immunosorbent assay; phenyl acetate method is used to determine serum levels of PON-1,all of the patients with acute cerebral infarction tested by NIHSS score,Glasgow coma scale and CT and MRI diagnosis.Results There is no statistical significance in average age,gender and Glasgow coma scale between control group and cerebral infarction one.It has significant difference on risk factors and PON-1 and ox-LDL levels.In patients with cerebral infarction NIHSS score increased with serum levels of ox-LDL while Glasgow score negatively correlated with serum levels of ox-LDL.The PON-1 serum level of cerebral infarction patients positively correlated with Glasgow score and negatively correlated with the NIHSS score.Conclusion The serum PON-1 and ox-LDL levels are closely related with neurological deficit in the patients of acute cerebral infarction.Serum levels of PON-1 and ox-LDL can indirectly reflect the acute cerebral infarction neurological symptoms.The serum levels of PON-1 and ox-LDL may be used to evaluate diagnosis and treatment of acute cerebral infarction effectively.

参考文献/References:

 [1] HUANG Q,LIU Y-h,YANG Q-d,et al.Human serum paraoxonase gene polymorphisms,Q192R and L55M,are not associated with the risk of cerebral infarction in Chinese Han population[J].Neurological Research,2006,28(5):549-554.
[2] TADA Y,YAGI K,UNO M,et al.Improvement of plasma biomarkers after switching stroke patients from other angiotensin II type I receptor blockers to olmesartan[J].Journal of Stroke and Cerebrovascular Diseases:the Official Journal of National Stroke Association,2015,24(7):1487-1492.
[3] ANAN F,SHIMOMURA T,KAKU T,et al.High-sensitivity C-reactive protein level is a significant risk factor for silent cerebral infarction in patients on hemodialysis[J].Metabolism-Clinical and Experimental,2008,57(1):66-70.
[4] ZHANG Jing-yu,LIU Bin,WANG Ya-nan,et al.Effect of rosuvastatin on OX40L and PPAR-γ expression in human umbilical vein endothelial cells and atherosclerotic cerebral infarction patients[J].Journal of Molecular Neuroscience:MN,2014,52(2):261-268.
[5] LI Qing,WANG Yi-ping,LI Hong-qi,et al.Ox-LDL influences peripheral Th17/Treg balance by modulating Treg apoptosis and Th17 proliferation in atherosclerotic cerebral infarction[J].Cellular Physiology and Biochemistry,2014,33(6):1849-1862.
[6] TRPKOVIC A,RESANOVIC I,STANIMIROVIC J,et al.Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases[J].Critical Reviews in Clinical Laboratory Sciences,2015,52(2):70-85.
[7] SHAO Peng,QU Da-jun,SONG Rui-ying,et al.Association between PON1 L55M polymorphism and ischemic stroke:a systematic review and meta-analysis[J].International Journal of Clinical and Experimental Medicine,2015,8(3):3429-3437.
[8] IÇME F,EREL Ö,AVCI A,et al.The relation between oxidative stress parameters,ischemic stroke,and hemorrhagic stroke[J].Turkish Journal of Medical Sciences,2015,45(4):947-953.
[9] MENINI T,GUGLIUCCI A.Paraoxonase 1 in neurological disorders[J].Redox Report:Communications in Free Radical Research,2014,19(2):49-58.
[10] WANG Lili,JIANG Jun,DU Lutao,et al.The prognostic value of serum pregnancy-associated plasma protein A,S100 and high sensitivity C-reactive protein in acute ischemic stroke patients without heparin administration[J].Clinical Biochemistry,2014,47(16/17):187-191.
[11] SU Jun-feng,HU Xiao-hui,LI Cheng-yan.Risk factors for clopidogrel resistance in patients with ischemic cerebral infarction and the correlation with ABCB1 gene rs1045642 polymorphism[J].Experimental and Therapeutic Medicine,2015,9(1):267-271.

相似文献/References:

[1]黄立宏 李刚 冯小芳等. 15d-PGJ2对糖尿病大鼠脑缺血再灌注损伤小胶质细胞活化及神经细胞凋亡的影响[J].卒中与神经疾病杂志,2016,23(03):149.[doi:10.3969/j.issn.1007-0478.2016.03.001]
　Huang Lihong,Li Gang,Feng Xiaofang,et al. Effect of 15d-PGJ2 on the activation of microglias and the apotosis of neurons after the injury of acute cerebral ischemia reperfusion in diabetic rats[J].Stroke and Nervous Diseases,2016,23(04):149.[doi:10.3969/j.issn.1007-0478.2016.03.001]
[2]黄锦丰 凌国源 玉石等. L-选择素在缺血性脑卒中患者外周血中的表达及其意义[J].卒中与神经疾病杂志,2016,23(03):154.[doi:10.3969/j.issn.1007-0478.2016.03.002]
　Huang Jinfeng,Ling Guoyuan,Yu Shi,et al. L-selectin in peripheral blood of patients with ischemic cerebral stroke and its significance[J].Stroke and Nervous Diseases,2016,23(04):154.[doi:10.3969/j.issn.1007-0478.2016.03.002]
[3]袁波 谭李红 谭莉等. 介入栓塞与陀螺旋转式60钴放射治疗系统联合治疗颅内巨大动静脉畸形15例疗效观察[J].卒中与神经疾病杂志,2016,23(03):157.[doi:10.3969/j.issn.1007-0478.2016.03.003]
　Yuan Bo,Tan Lihong,Tan Li,et al. Clinical analysis of 15 cases combined treatment of endovascular embolization and gyro 60 cobalt radiation system in giant cerebral arteriovenous malformations[J].Stroke and Nervous Diseases,2016,23(04):157.[doi:10.3969/j.issn.1007-0478.2016.03.003]
[4]王慧玲 黄朝云. 脑卒中后抑郁合并认知损害的磁共振扩散张量成像研究[J].卒中与神经疾病杂志,2016,23(03):160.[doi:10.3969/j.issn.1007-0478.2016.03.004]
　Huiling,Huang Chaoyun.. A diffusion tensor imaging study in patients with post-stroke depression combined with cognitive impairmentWang[J].Stroke and Nervous Diseases,2016,23(04):160.[doi:10.3969/j.issn.1007-0478.2016.03.004]
[5]吕敏 吕琳 温慧军等. ABCD2评分预测头昏患者发生缺血性脑血管事件风险的研究[J].卒中与神经疾病杂志,2016,23(03):164.[doi:10.3969/j.issn.1007-0478.2016.03.005]
　Lv Min,Lv Lin,Wen Huijun,et al. Application of the ABCD2 score to identify ischemic cerebrovascular events of patients with dizziness[J].Stroke and Nervous Diseases,2016,23(04):164.[doi:10.3969/j.issn.1007-0478.2016.03.005]
[6]李岚. 肌电图定位定量电刺激治疗上肢周围神经损伤的临床分析[J].卒中与神经疾病杂志,2016,23(03):167.[doi:10.3969/j.issn.1007-0478.2016.03.006]
　Li Lan.. The clinical analysis of EMG quantitative electrical stimulation in the treatment of peripheral nerve injury of upper limb[J].Stroke and Nervous Diseases,2016,23(04):167.[doi:10.3969/j.issn.1007-0478.2016.03.006]
[7]李瑾 陈黛琪. 无创机械通气在重症肌无力危象治疗中的疗效[J].卒中与神经疾病杂志,2016,23(03):170.[doi:10.3969/j.issn.1007-0478.2016.03.007]
　Li Jin,Chen Daiqi.. Therapeutic effect of noninvasive mechanical ventilation in the treatment of myasthenia gravis crisis[J].Stroke and Nervous Diseases,2016,23(04):170.[doi:10.3969/j.issn.1007-0478.2016.03.007]
[8]强毅娜 高杰. 富亮氨酸胶质瘤失活1蛋白抗体阳性相关免疫脑炎1例临床分析并文献复习[J].卒中与神经疾病杂志,2016,23(03):174.[doi:10.3969/j.issn.1007-0478.2016.03.008]
　Qiang Yina,Gao Jie.. Clinical analysis of 1 patient with leucine-rich glioma inactivated-1 protein antibody positive limbic encephalitis:A case report and review of literature[J].Stroke and Nervous Diseases,2016,23(04):174.[doi:10.3969/j.issn.1007-0478.2016.03.008]
[9]宋楠 王红梅. 针吸型肌肉活检联合免疫荧光在假肥大型肌营养不良诊断中的应用[J].卒中与神经疾病杂志,2016,23(03):177.[doi:10.3969/j.issn.1007-0478.2016.03.009]
　Song Nan,Wang Hongmei.. The application of needle muscle biopsy combined with immunofluorescence in diagnosing of pseudohypertrophic muscular dystrophy[J].Stroke and Nervous Diseases,2016,23(04):177.[doi:10.3969/j.issn.1007-0478.2016.03.009]
[10]杨小华 李格 管萍. 脑出血迟发型血肿扩大的机制探讨和治疗对策[J].卒中与神经疾病杂志,2016,23(03):180.[doi:10.3969/j.issn.1007-0478.2016.03.010]
　[J].Stroke and Nervous Diseases,2016,23(04):180.[doi:10.3969/j.issn.1007-0478.2016.03.010]

备注/Memo

备注/Memo:
 (2016-02-19收稿 2016-04-10修回)
更新日期/Last Update: 2016-08-31