[1]孙光文 徐仕皓 王媛媛 毛瑞 杨文琼.PTX3联合LP-PLA2水平与急性缺血性脑卒中合并颈动脉狭窄的关系[J].卒中与神经疾病杂志,2023,30(03):273-277.[doi:10.3969/j.issn.1007-0478.2023.03.008]
　Sun Guangwen*,Xu Shihao,Wang Ruanruan,et al.Correlation analysis of PTX3 combined with LP-PLA2 in carotid stenosis in acute ischemic stroke[J].Stroke and Nervous Diseases,2023,30(03):273-277.[doi:10.3969/j.issn.1007-0478.2023.03.008]
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PTX3联合LP-PLA2水平与急性缺血性脑卒中合并颈动脉狭窄的关系()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第30卷
期数:
2023年03期
页码:
273-277
栏目:
论著
出版日期:
2023-06-20

文章信息/Info

Title:
Correlation analysis of PTX3 combined with LP-PLA2 in carotid stenosis in acute ischemic stroke
文章编号:
1007-0478(2023)03-0273-05
作者:
孙光文 徐仕皓 王媛媛 毛瑞 杨文琼
442008 锦州医科大学国药东风总医院研究生培养基地(孙光文); 湖北医药学院附属国药东风总医院神经内科[徐仕皓 王媛媛 毛瑞 杨文琼(通信作者)]
Author(s):
Sun Guangwen*;  Xu Shihao;  Wang Ruanruan;  et al.
* Neurological Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan Hubei 442008
关键词:
急性缺血性脑卒中; 颈动脉粥样硬化; 正五聚蛋白3; 脂蛋白相关磷脂酶A2; 颈动脉狭窄
Keywords:
Acute ischemic stroke; Carotid atherosclerosis; Pentraxins; Lipoprotein associated phospholipid A2; Carotid stenosis
分类号:
R743.3
DOI:
10.3969/j.issn.1007-0478.2023.03.008
文献标志码:
A
摘要:
目的 探讨血浆正五聚蛋白(Pentraxins,PTX3)联合脂蛋白相关磷脂酶A2(Lipoprotein associated phospholipid A2,LP-PLA2)水平与急性缺血性脑卒中(Acute ischemic stroke,AIS)合并颈动脉狭窄的关系。方法 选择127例AIS患者,根据全脑血管造影表现分为AIS合并颈动脉狭组97例与AIS无颈动脉狭窄组30例; 根据颈动脉狭窄程度分为轻度狭窄组(n=32)、中度狭窄组(n=32)和重度狭窄组(n=33)。另选取同期体检健康者62例为对照组。采用酶联免疫吸附测定法检测所有研究对象的血浆PTX3,LP-PLA2水平; Logistic回归分析血清PTX3,LP-PLA2水平对AIS颈动脉狭窄程度的影响。结果 AIS合并颈动脉狭窄组血浆PTX3,LP-PLA2水平高于对照组及无颈动脉狭窄组(P<0.05); AIS伴颈动脉重度狭窄组血浆PTX3,LP-PLA2水平高于中度狭窄组及轻度狭窄组(P<0.005)。中重度脑卒中组血浆PTX3,LP-PLA2水平高于轻度脑卒中组(P<0.05)。多因素Logistics回归分析显示,PTX3,LP-PLA2水平是AIS合并颈动脉狭窄的影响因素(P<0.05)。结论 AIS患者血浆PTX3,LP-PLA2表达水平与颈动脉狭窄、神经功能缺损严重程度有关。
Abstract:
ObjectiveTo investigate the relationship between carotid artery stenosis and plasma pentraxins(PTX3)and lipoprotein- associated phospholipase A2(LP-PLA2)in patients with acute ischemic stroke(AIS).Methods According to the results of whole cerebral angiography, 127 patients with AIS were divided into AIS with carotid artery stenosis group(n=97)and AIS without carotid artery stenosis group(n=30). The degree of carotid stenosis was divided into mild stenosis group(n=32), moderate stenosis group(n=32)and severe stenosis group(n=33), and 62 healthy controls were selected in the same period. The plasma levels of PTX3 and LP-PLA2 were measured by enzyme-linked immunosorbent assay(Elisa), and the levels of PTX3 and LP-PLA2 in AIS group were compared. The levels of plasma PTX3 and LP-PLA2 in control group and mild, moderate and severe carotid stenosis groups. Logistic regression analysis was used to examine the effect of serum PTX3 and LP-PLA2 levels on the degree of carotid artery stenosis in AIS.Results The levels of plasma PTX3 and LP-PLA2 in AIS with carotid stenosis group were higher than those in control group and non-carotid stenosis group(P<0.05). The levels of recombinant plasma PTX3 and LP-PLA2 in AIS with severe carotid stenosis group were higher than those in moderate stenosis group and mild stenosis group(P<0.005), and the levels of plasma PTX3 and LP-PLA2 in high NIHSS score group were higher than those in low group(P<0.005). Multivariate Logistics regression analysis showed that PTX3 and LP-PLA2 were independent influencing factors of AIS and carotid stenosis.Conclusion The level of plasma PTX3 and LP-PLA2 expression in patients with AIS is closely related to carotid artery stenosis and the severity of neurological impairment.

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备注/Memo

备注/Memo:
基金项目:湖北省卫计委(WJ2019M055); 国药东风总医院院内项目(2021S02)
更新日期/Last Update: 2023-06-20