[1]王海滨,门庆玲,周文龙,等.基于质谱法探讨血浆代谢物和老年人阿尔茨海默病神经退行性变的潜在联系[J].卒中与神经疾病杂志,2023,30(05):440-444.[doi:10.3969/j.issn.1007-0478.2023.05.003]
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基于质谱法探讨血浆代谢物和老年人阿尔茨海默病神经退行性变的潜在联系()
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《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第30卷
期数:
2023年05期
页码:
440-444
栏目:
阿尔茨海默病
出版日期:
2023-10-20

文章信息/Info

文章编号:
1007-0478(2023)05-0440-05
作者:
王海滨门庆玲周文龙郭海志蔡艳丽
641300 四川省资阳市第一人民医院(四川大学华西医院资阳医院)神经内科(王海滨 周文龙 郭海志 蔡艳丽),心血管内科(门庆玲)
关键词:
质谱法 阿尔茨海默病 老年人 神经退行性 丙酮酸 乳酸
分类号:
R742
DOI:
10.3969/j.issn.1007-0478.2023.05.003
文献标志码:
A
摘要:
目的 探讨质谱法测定的血浆代谢物(丙酮酸和乳酸)水平与老年人阿尔茨海默病(Alzheimer's disease,AD)神经退行性变的相关性。方法 2020年1月-2022年3月76名参与者[52名认知功能正常,9例轻度认知功能障碍(Mild cognitive impairment,MCI),15例AD痴呆(AD dementia,ADD)]参与了这项研究; 通过正电子发射断层成像(Positron emission tomography,PET)成像评估大脑中Tau沉积的量,质谱法测定血浆乳酸、丙酮酸水平和血浆淀粉样蛋白β1-42(Amyloid-β1-42,Aβ1-42)水平。结果 随着脑Tau病变进展(Braak分期0~VI),血浆乳酸[F(3,47)=3.114,P=0.035]、丙酮酸[F(3,47)=4.505,P=0.007]、乳酸/Aβ1-42[F(3,47)=3.418,P=0.031]和丙酮酸/Aβ1-42[F(3,47)=11.558,P<0.001]逐渐增高; 血浆乳酸(r=0.36,P=0.006)、丙酮酸(r=0.32,P=0.008)、乳酸/Aβ1-42(r=0.44,P=0.003)和丙酮酸/Aβ1-42(r=0.52,P<0.001)与大脑中AD特征区域中的Tau负荷高度显著相关; 与Tau-PET(-)受试者比较,Tau-PET(+)受试者的血浆乳酸、丙酮酸、乳酸/Aβ1-42、丙酮酸/Aβ1-42显著更高(t=3.024、4.762、4.815、6.103,P均<0.05); 受试者工作特征曲线(Receiver operating curve,ROC)显示,血浆丙酮酸水平/Aβ1-42区分Tau-PET-(-)和Tau-PET(+)受试者方面的AUC值(AUC=0.891; 敏感性为80.0%; 特异性为91.4%)最高。结论 血浆丙酮酸水平/Aβ1-42是预测大脑中AD相关Tau病理学的潜在生物标志物。

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备注/Memo

备注/Memo:
基金项目:四川省卫生健康科研基金项目(20210181)
更新日期/Last Update: 2023-10-20