[1]付群 刘尊敬 崔丹.老年急性脑梗死患者血清CCL2、CCL3表达水平与脑梗死体积、神经功能缺损程度的关系[J].卒中与神经疾病杂志,2019,26(01):8-12.[doi:10.3969/j.issn.1007-0478.2019.01.002]
　Fu Qun*,Liu Zunjing,Cui Dan.The relationships between the expression levels of CCL2, CCL3 and cerebral infarct volume, the degree of neurological deficit in elderly patients with acute cerebral infarction[J].Stroke and Nervous Diseases,2019,26(01):8-12.[doi:10.3969/j.issn.1007-0478.2019.01.002]
点击复制

老年急性脑梗死患者血清CCL2、CCL3表达水平与脑梗死体积、神经功能缺损程度的关系()
分享到：

《卒中与神经疾病》杂志[ISSN:1007-0478/CN:42-1402/R]

卷:
第26卷
期数:
2019年01期
页码:
8-12
栏目:
论 著
出版日期:
2019-02-26

文章信息/Info

Title:
The relationships between the expression levels of CCL2, CCL3 and cerebral infarct volume, the degree of neurological deficit in elderly patients with acute cerebral infarction
文章编号:
1007-0478(2019)01-0008-05
作者:
付群 刘尊敬 崔丹
100000 北京,煤炭总医院内干病房(付群); 中日友好医院神经内科(刘尊敬); 密云区医院神经内科(崔丹)
Author(s):
Fu Qun*;  Liu Zunjing;  Cui Dan
*Dry Ward, Coal General Hospital,Beijing 100028
关键词:
趋化因子CC基序配体2 趋化因子CC基序配体3 急性脑梗死 脑梗死体积 神经功能缺损程度
Keywords:
Chemokine(C-C motif)ligand 2 Chemokine(C-C motif)ligand 3 Acute cerebral infarction Infarct volume Degree of neurological deficit
分类号:
R743.3
DOI:
10.3969/j.issn.1007-0478.2019.01.002
文献标志码:
A
摘要:
目的 探讨老年急性脑梗死患者血清趋化因子CC基序配体2(CCL2)、趋化因子CC基序配体3(CCL3)的表达水平与脑梗死体积、神经功能缺损程度的关系。方法 选取2016年8月-2017年8月于本院收治的老年急性脑梗死患者124例,并选择同期体检健康者78例作为对照组,应用Pullicino公式计算脑梗死体积将患者分为小梗死组(n=56)、中梗死组(n=41)、大梗死组(n=27),根据美国国立卫生研究院卒中量表(NIHSS)评分将患者分为轻度组(n=59)、中度组(n=37)、重度组(n=28),采取酶联免疫吸附法检测血清CCL2、CCL3水平,血清CCL2、CCL3水平与脑梗死体积、神经功能缺损程度间关系采用Pearson相关分析,影响急性脑梗死发生的危险因素应用多因素Logistic回归分析。结果 小、中、大梗死组血清CCL2、CCL3水平显著高于对照组,中、大梗死组血清CCL2、CCL3水平显著高于小梗死组,且大梗死组血清CCL2、CCL3水平显著高于中梗死组(P<0.05); 轻、中、重度组血清CCL2、CCL3水平显著高于对照组,中、重度组血清CCL2、CCL3水平显著高于轻度组,且重度组血清CCL2、CCL3水平显著高于中度组(P<0.05); 患者血清CCL2、CCL3水平与脑梗死体积分别呈显著正相关(r=0.349/0.481,P<0.05); 患者血清CCL2、CCL3水平与NIHSS评分分别呈显著正相关(r=0.493/0.650,P<0.05); 低密度脂蛋白胆固醇(LDL-C)、空腹血糖、CCL2、CCL3水平是影响急性脑梗死发生的危险因素(OR=1.912,1.624,2.272,2.082,95%CI=1.341～2.728,1.436～1.836,1.372～3.764,1.623～2.671,P<0.05)。结论 老年急性脑梗死患者血清CCL2、CCL3水平与脑梗死体积、神经功能缺损程度均呈显著正相关,可作为反映急性脑梗死患者的病情进展及严重程度的有效指标。
Abstract:
ObjectiveTo investigate the relationships between the expression levels of chemokine(C-C motif)ligand 2(CCL2),chemokine(C-C motif)ligand 3(CCL3)and cerebral infarct volume, the degree of neurological deficit in elderly patients with acute cerebral infarction.Methods 124 elderly patients with acute cerebral infarction were selected from August 2016 to August 2017, and 78 healthy people were selected as control group. Pullicino formula was used to calculate cerebral infarct volume, and the patients were divided into small infarction group(n=56), middle infarction group(n=41)and large infarction group(n=27), the patients were divided into mild group(n=59), moderate group(n=37)and severe group(n=28)according to the national institutes of health stroke scale(NIHSS), enzyme-linked immunosorbent assay was used to detect serum CCL2 and CCL3 levels, the correlations between serum CCL2, CCL3 levels and cerebral infarct volume, the degree of neurological deficit were analyzed by Pearson correlation analysis, multivariate Logistic regression analysis was used to determine the risk factors of acute cerebral infarction.Results The serum CCL2 and CCL3 levels in small, middle and large infarction groups were significantly higher than those in the control group, the serum CCL2 and CCL3 levels in the middle and large infarction groups were significantly higher than those in the small infarction group, the serum CCL2 and CCL3 levels in the large infarction group were significantly higher than those in the middle infarction group(P<0.05).The serum CCL2 and CCL3 levels in the mild, moderate and severe groups were significantly higher than those in the control group, serum CCL2 and CCL3 levels in moderate and severe groups were significantly higher than those in mild group, the serum CCL2 and CCL3 levels in severe group were significantly higher than those in moderate group(P<0.05). There were significantly positive correlations between serum CCL2, CCL3 levels and cerebral infarct volume(r=0.349/0.481,P<0.05). There were significantly positive correlations between serum CCL2, CCL3 levels and NIHSS score(r=0.493/0.650,P<0.05). Low density lipoprotein cholesterol(LDL-C), fasting blood glucose, CCL2 and CCL3 were the risk factors of acute cerebral infarction(OR=1.912,1.624,2.272,2.082, 95% CI=1.341～2.728,1.436～1.836,1.372～3.764,1.623～2.671,P<0.05).Conclusion Serum CCL2 and CCL3 levels in elderly patients with acute cerebral infarction were positively correlated with cerebral infarct volume and the degree of neurological deficit, which could be used as an effective index to reflect the progress and severity of acute cerebral infarction.

参考文献/References:


[1] 李晓波,黄敏,陈蓓蕾,等.急性脑梗死合并心房颤动患者的重组组织型纤溶酶原激活剂静脉溶栓治疗[J].中华老年医学杂志,2016,35(1):22-26.
[2] 冯锦丽,王卫.急性脑梗死患者循环miR-124表达水平与脑梗死体积,神经功能缺损程度的关系及其诊断价值[J].卒中与神经疾病,2018,25(1):21-24,38.
[3] 郭春艳.复发性流产患者血液流变学及血清CC型趋化因子配体2,白介素-10,干扰素-γ水平变化及意义[J].中国临床医生杂志,2017,45(8):94-96.
[4] 王新德.各类脑血管疾病诊断要点[J].临床荟萃,1988,29(8): 367-368.
[5] Kwah LK,Diong J.National institutes of health stroke scale(NIHSS)[J].J Physiother,2014,60(1):61.
[6] Saito T,Hayashi K,Nakazawa H,et al.Clinical characteristics and lesions responsible for swallowing hesitation after acute cerebral infarction[J].Dysphagia,2016,31(4):567-573.
[7] 刘雅宝,纪盛章,张伯生,等.颈动脉斑块与急性脑梗死体积的相关性研究[J].中国临床医学影像杂志,2018,29(3):153-157.
[8] 柳丰慧,张可帅.血清白介素6、基质金属蛋白酶9、基质金属蛋白酶抑制剂1、超敏C反应蛋白及神经生长因子水平与急性脑梗死患者神经功能缺损程度的关系研究[J].实用心脑肺血管病杂志,2017,25(1):35-38.
[9] 毛文静,任伯,刘斌,等.急性脑梗死患者脑侧支循环形成情况及其对梗死体积和预后的影响[J].中国煤炭工业医学杂志,2017,20(7):761-764.
[10] 王莉晓,刘志杰,王男,等.趋化因子CCL2、CCL7和CCR2在淡水溺死后大鼠肺组织及血清中的表达[J].中国法医学杂志,2018,33(3):253-257.
[11] Khan UA,Hashimi SM,Bakr MM,et al.CCL2 and CCR2 are Essential for the Formation of Osteoclasts and Foreign Body Giant Cells[J].J Cell Biochem,2016,117(2):382-389.
[12] 李兵,傅尧,符义富,等.口腔鳞状细胞癌患者血清中CCL2和VEGF表达的初步研究[J].现代检验医学杂志,2017,32(4):64-66, 71.
[13] Chang AL,Miska J,Wainwright DA,et al.CCL2 produced by the glioma microenvironment is essential for the recruitment of regulatory T cells and Myeloid-Derived suppressor cells[J].Cancer Res,2016,76(19):5671-5682.
[14] 崔紫阳,王红阳,王昊辰,等.不同程度肺气肿表型慢阻肺患者血清同型半胱氨酸,趋化因子配体2水平与认知功能障碍的关系[J].中国呼吸与危重监护杂志,2018,17(1):15-19.
[15] 刘莉,李士林,张仁芳,等.类1型-趋化因子配体3和趋化因子配体4基因与艾滋病患者抗病毒治疗后免疫重建的相关性[J].中华传染病杂志,2015,33(2):83-86.
[16] Sivina M,Werner L,Rassenti L,et al.Dynamic changes in CCL3 and CCL4 plasma concentrations in patients with chronic lymphocytic leukaemia managed with observation[J].Br J Haematol,2018,180(4):597-600.
[17] Janssen K,Rickert M,Clarner T,et al.Absence of CCL2 and CCL3 ameliorates central nervous system grey matter but not white matter demyelination in the presence of an intact Blood-Brain barrier[J].Mol Neurobiol,2016,53(3):1551-1564.
[18] 蔡楠,何飞,王芳,等.急性脑梗死患者血清神经元特异性烯醇化酶水平与梗死部位,体积及神经功能缺损的相关性[J].山东医药,2018,58(1):73-75.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(编号为30973900)
作者单位:100000 北京,煤炭总医院内干病房(付群); 中日友好医院神经内科(刘尊敬); 密云区医院神经内科(崔丹)
更新日期/Last Update: 2019-02-20