参考文献/References:
[1] Manning NW, Campbell BC, Oxley TJ, et al. Acute ischemic stroke: time, penumbra, and reperfusion[J]. Stroke, 2014, 45(2): 640-644.
[2] Gao Y, Wen LL, Yang X, et al. Pathological mechanism of focal cerebral ischemia and reperfusion injuries in mice[J]. J Biol Regul Homeost Agents, 2019, 33(5): 1507-1513.
[3] Li XQ, Yu Q, Fang B, et al.Knockdown of the AIM2 molecule attenuates ischemia-reperfusion-induced spinal neuronal pyroptosis by inhibiting AIM2 inflammasome activation and subsequent release of cleaved Caspase-1 and IL-1β[Z],2019:107661.
[4] Pan J, Han L, Guo J, et al. AIM2 accelerates the atherosclerotic plaque progressions in ApoE-/- mice[J]. Biochem Biophys Res Commun, 2018, 498(3): 487-494.
[5] Buerckstuemmer T, Baumann C, Blueml SA, et al. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome[J]. Nat Immunol, 2009, 10(3): 266-272.
[6] Albrecht M, Choubey D, Lengauer T. The HIN domain of IFI-200 proteins consists of two OB folds[J]. Biochem Biophys Res Commun, 2005, 327(3): 679-687.
[7] Hornung V, Ablasser A, Charrel-Dennis M, et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC[J]. Nature, 2009, 458(7237): 514-518.
[8] Jin TC, Perry A, Jiang JS, et al. Structures of the HIN domain: DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor[J]. Immunity, 2012, 36(4): 561-571.
[9] Wang B, Yin Q. AIM2 inflammasome activation and regulation: A structural perspective[J]. J Struct Biol, 2017, 200(3): 279-282.
[10] Morrone SR, Matyszewski M, Yu X, et al.Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC[Z],2015:7827.
[11] Fernandes-Alnemri T, Yu JW, Datta P, et al. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA[J]. Nature, 2009, 458(7237): 509-513.
[12] Dick MS, Sborgi L, Rühl S, et al.ASC filament formation serves as a signal amplification mechanism for inflammasomes[Z], 2016:11929.
[13] Broz P, Dixit VM. Inflammasomes: mechanism of assembly, regulation and signalling[J]. Nat Rev Immunol, 2016, 16(7): 407-420.
[14] Nina VO, Mohamed L. Caspases in cell death, inflammation, and disease[J]. Immunity, 2019, 50(6): 1352-1364.
[15] Hu B, Jin C, Li HB, et al. The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury[J]. Science, 2016, 354(6313): 765-768.
[16] Kaminski JJ, Schattgen SA, Tzeng TC, et al. Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation[J]. J Immunol, 2013, 191(7): 3876-3883.
[17] Devi S, Stehlik C, Dorfleutner A. An update on CARD only proteins(COPs)and PYD only proteins(POPs)as inflammasome regulators[J]. Int J Mol Sci, 2020, 21(18): 6901.
[18] Roberts TL, Idris A, Dunn JA, et al. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA[J]. Science, 2009, 323(5917): 1057-1060.
[19] Yin Q, Sester DP, Tian Y, et al. Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation[J]. Cell Rep, 2013, 4(2): 327-339.
[20] Wang PH, Ye ZW, Deng JJ, et al. Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16[J]. EMBO Rep, 2018, 19(10): e45737.
[21] Liu T, Tang Q, Liu K, et al. TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-Dependent selective autophagy[J]. Cell Rep, 2016, 16(7): 1988-2002.
[22] Sekerdag E, Solaroglu I, Gursoy-Ozdemir Y. Cell death mechanisms in stroke and novel molecular and cellular treatment options[J]. Curr Neuropharmacol, 2018, 16(9): 1396-1415.
[23] Miao EA, Rajan JV, Aderem A. Caspase-1-induced pyroptotic cell death[J]. Immunol Rev, 2011, 243(1): 206-214.
[24] Galluzzi L, Vitale I, Abrams JM, et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012[J]. Cell Death Differ, 2012, 19(1): 107-120.
[25] An S, Hu H, Li Y, et al. Pyroptosis plays a role in osteoarthritis[J]. Aging Dis, 2020, 11(5): 1146-1157.
[26] Cheng Q, Pan J, Zhou ZL, et al.Caspase-11/4 and gasdermin D-mediated pyroptosis contributes to podocyte injury in mouse diabetic nephropathy[Z], 2020.
[27] Tu Y, Guo C, Song F, et al. Mild hypothermia alleviates diabetes aggravated cerebral ischemic injury via activating autophagy and inhibiting pyroptosis[J]. Brain Res Bull, 2019, 150: 1-12.
[28] Pang Y, Zhang PC, Lu RR, et al.Andrade-Oliveira salvianolic acid B modulates caspase-1-Mediated pyroptosis in renal Ischemia-Reperfusion injury via Nrf2 pathway[Z], 2020:541426.
[29] An P, Xie J, Qiu S, et al. Hispidulin exhibits neuroprotective activities against cerebral ischemia reperfusion injury through suppressing NLRP3-mediated pyroptosis[J]. Life Sci, 2019, 232: 116599.
[30] Liang J, Wang Q, Li JQ, et al.Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485/AIM2 axis[Z], 2020:113139.
[31] Zhang MJ, Zhao QC, Xia MX, et al. The HDAC3 inhibitor RGFP966 ameliorated ischemic brain damage by downregulating the AIM2 inflammasome[J]. FASEB J, 2020, 34(1): 648-662.
[32] Gelderblom M, Sobey CG, Kleinschnitz C, et al. Danger signals in stroke[J]. Ageing Res Rev, 2015, 24(Pt A): 77-82.
[33] Zhu S, Zhang Z, Jia LQ, et al. Valproic acid attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-pyroptosis pathways[J]. Neurochem Int, 2019, 124: 141-151.
[34] Dong Z, Pan K, Pan J, et al. The possibility and molecular mechanisms of cell pyroptosis after cerebral ischemia[J]. Neurosci Bull, 2018, 34(6): 1131-1136.
[35] Li Q, Cao Y, Dang C, et al. Inhibition of double-strand DNA-sensing cGAS ameliorates brain injury after ischemic stroke[J]. EMBO Mol Med, 2020, 12(4): e11002.
[36] Habib P, Harms J, Zendedel A, et al. Gonadal hormones E2 and P mitigate cerebral Ischemia-Induced upregulation of the AIM2 and NLRC4 inflammasomes in rats[J]. Int J Mol Sci, 2020, 21(13): 4795.
[37] Diaz-Ca?stro C, Reiner MF, Bonetti NR, et al. AP-1(activated protein-1)transcription factor JunD regulates ischemia/reperfusion brain damage via IL-1β(interleukin-1β)[J]. Stroke, 2019, 50(2): 469-477.
[38] Chen X, Hovanesian V, Naqvi S, et al. Systemic infusions of anti-interleukin-1β neutralizing antibodies reduce short-term brain injury after cerebral ischemia in the ovine fetus[J]. Brain Behav Immun, 2018, 67: 24-35.