参考文献/References:
[1] Galluzzi L, Vitale I, Aaronson SA, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018[J]. Cell Death Differ, 2018, 25(3): 486-541.
[2] Aachoui Y, Sagulenko V, Miao AE, et al. Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection[J]. Curr Opin Microbiol, 2013, 16(3): 319-326.
[3] Mangan M, Olhava EJ, Roush WR, et al. Targeting the NLRP3 inflammasome in inflammatory diseases[published correction appears in Nat Rev Drug Discov.2018 Sep; 17(9):688].Nat Rev Drug Discov[J]. 588‐606.doi:10.1038/nrd, 2018, 17(8): 97.
[4] Feng SY, Fox D, Man SM. Mechanisms of gasdermin family members in inflammasome signaling and cell death[J]. J Mol Biol, 2018, 430(18): 3068-3080.
[5] Zhao Y, Shao F. The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus[J]. Immunol Rev, 2015, 265(1): 85-102.
[6] Mitchell PS, Sandstrom A, Vance RE.The NLRP1 inflammasome:new mechanistic insights and unresolved mysteries[Z],2019:015.
[7] Kovacs SB, Miao EA. Gasdermins: effectors of pyroptosis[J]. Trends Cell Biol, 2017, 27(9): 673-684.
[8] Zhaolin Z, Guohua L, Shiyuan W, et al. Role of pyroptosis in cardiovascular disease[J]. Cell Prolif, 2019, 52(2): e12563.
[9] Vande Walle L, Pyroptosis LM. Curr Biol[J]. R568-R572.doi:10.1016/j.cub, 2016, 26(13): 019.
[10] Akosile WV, Ptsd I.NLRP3 is associated with coronary artery disease in Vietnam veterans[Z],2019:31639433.
[11] Toldo S, Mauro AG, Cutter Z, et al. Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury[J]. Am J Physiol Heart Circ Physiol, 2018, 315(6): H1553-H1568.
[12] Hang L, Peng Y, Xiang R, et al. Ox-LDL causes endothelial cell injury through ASK1/NLRP3-Mediated inflammasome activation via endoplasmic reticulum stress[J]. Drug Des Devel Ther, 2020, 14(14): 731-744.
[13] Rajam?i K, Lappalainen J, O?ni K, et al. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel Link between cholesterol metabolism and inflammation[J]. PLoS One, 2010, 5(7): e11765.
[14] De Vasconcelos NM, Van Opdenbosch N, Van Gorp H, et al. Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture[J]. Cell Death Differ, 2019, 26(1): 146-161.
[15] Sarkar S, Rokad D, Malovic E, et al. Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells[J]. Sci Signal, 2019, 12(563): eaat9900.
[16] Yajima N, Takahashi M, Morimoto H, et al. Critical role of bone marrow apoptosis-associated speck-like protein, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice[J]. Circulation, 2008, 117(24): 3079-3087.
[17] Swanson KV, Deng M, Ting JP. The NLRP3 inflammasome: molecular activation and regulation to therapeutics[J]. Nat Rev Immunol, 2019, 19(8): 477-489.
[18] Rayasam A, Hsu M, Kijak JA, et al. Immune responses in stroke: how the immune system contributes to damage and healing after stroke and how this knowledge could be translated to better cures?[J]. Immunology, 2018, 154(3): 363-376.
[19] Crilly S, Njegic A, Parry-Jones AR, et al. Using zebrafish larvae to study the pathological Consequences of hemorrhagic stroke[J]. J Vis Exp, 2019(148): 10.
[20] Fann DY, Santro T, Manzanero S, et al.Intermittent fasting attenuates inflammasome activity in ischemic stroke[Z],2014:017.
[21] Boucher D, Monteleone M, Coll RC, et al. Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity[J]. J Exp Med, 2018, 215(3): 827-840.
[22] Taabazuing CY, Okondo MC, Bachovchin DA. Pyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages[J]. Cell Chem Biol, 2017, 24(4):507-514, e4.
[23] Lee E, Hwang I, Park S, et al. MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration[J]. Cell Death Differ, 2019, 26(2): 213-228.
[24] Li J, Hao JH, Yao D, et al. Caspase-1 inhibition prevents neuronal death by targeting the canonical inflammasome pathway of pyroptosis in a murine model of cerebral ischemia[J]. CNS Neurosci Ther, 2020, 26(9): 925-939.
[25] Li S, Wu Y, Yang D, et al. Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis[J]. J Exp Med, 2019, 216(11): 2562-2581.
[26] Xu P, Zhang X, Liu Q, et al. Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke[J]. Cell Death Dis, 2019, 10(8): 555.
[27] Cristina de Brito Toscano E, Leandro Marciano Vieira é, Boni Rocha Dias B, et al. NLRP3 and NLRP1 inflammasomes are up-regulated in patients with mesial temporal lobe epilepsy and may contribute to overexpression of caspase-1 and IL-β in sclerotic hippocampi[J]. Brain Res, 2020, 29:147230.
[28] Gon?lves AV, Margolis SR, Quirino G, et al. Gasdermin-D and caspase-7 are the key caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of legionella pneumophila[J]. PLoS Pathog, 2019, 15(6): e1007886.
[29] Bassil F, Fernagut PO, Bezard E, et al. Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy[J]. Proc Natl Acad Sci USA, 2016, 113(34): 9593-9598.
[30] Chivero.Thangaraj a,tripathi a,periyasamy P,Guo ML,Buch S[Z],2021.
[31] Heneka MT, Mcmanus RM, Latz E. Inflammasome signalling in brain function and neurodegenerative disease[J]. Nat Rev Neurosci, 2018, 19(10): 610-621.
[32] Mamik MK, Power C. Inflammasomes in neurological diseases: emerging pathogenic and therapeutic concepts[J]. Brain, 2017, 140(9): 2273-2285.
[33] Adamczak SE. de rivero vaccari JP,dale G,brand FJ 3rd,nonner D,bullock Mr,dahl GP,dietrich WD,keane RW[J]. Pyroptotic neuronal cell death mediated by the AIM2 inflammasome.J Cereb Blood Flow Metab, 2014, 34(4): 621-629.
[34] Gustin A, Kirchmeyer M, Koncina E, et al. NLRP3 inflammasome is expressed and functional in mouse brain microglia but not in astrocytes[J]. PLoS One, 2015, 10(6): e0130624.
[35] Ebrahimi T, Rust M, Kaiser SN, et al. α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β(1-42)-stimulated murine astrocytes[J]. J Neuroinflammation, 2018, 15(1): 282.
[36] Feng J, Li M, Wei Q, et al. Unconjugated bilirubin induces pyroptosis in cultured rat cortical astrocytes[J]. J Neuroinflammation, 2018, 15(1): 23.