参考文献/References:
[1] Linkermann A, Green DR. Necroptosis[J]. N Engl J Med, 2014, 370(5): 455-465.
[2] Li JX, Mcquade T, Siemer AB, et al. The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis[J]. Cell, 2012, 150(2): 339-350.
[3] Wang Z, Jiang H, Chen S, et al. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways[J]. Cell, 2012, 148(1/2): 228-243.
[4] Zhang M, Li J, Geng R, et al. The inhibition of ERK activation mediates the protection of necrostatin-1 on glutamate toxicity in HT-22 cells[J]. Neurotox Res, 2013, 24(1): 64-70.
[5] Zhang DW, Shao J, Lin J, et al. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis[J]. Science, 2009, 325(5938): 332-336.
[6] Zhang Y, Su SS, Zhao S, et al. RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome[J]. Nat Commun, 2017, 8:14329.
[7] Liu L, Wang D, Wong KS, et al. Stroke and stroke care in China: huge burden, significant workload, and a National priority[J]. Stroke, 2011, 42(12): 3651-3654.
[8] Datta A, Sarmah D, Mounica L, et al. Cell death pathways in ischemic stroke and targeted pharmacotherapy[J]. Transl Stroke Res, 2020, 11(6): 1185-1202.
[9] Liu Q, Zhou S, Wang Y, et al. A feasible strategy for focal cerebral ischemia-reperfusion injury: remote ischemic postconditioning[J]. Neural Regen Res, 2014, 9(15): 1460-1463.
[10] Vieira M, Fernandes J, Carreto L, et al. Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3[J]. Neurobiol Dis, 2014, 68: 26-36.
[11] Font-Belmonte E, Ugidos IF, Santos-Galdiano M, et al. Post-ischemic salubrinal administration reduces necroptosis in a rat model of global cerebral ischemia[J]. J Neurochem, 2019, 151(6): 777-794.
[12] Tian J, Guo S, Chen H, et al. Combination of emricasan with ponatinib synergistically reduces ischemia/reperfusion injury in rat brain through simultaneous prevention of apoptosis and necroptosis[J]. Transl Stroke Res, 2018, 9(4): 382-392.
[13] Yin B, Xu Y, Wei RL, et al. Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury[J]. Brain Res, 2015, 1609: 63-71.
[14] Xu Y, Wang J, Song X, et al. RIP3 induces ischemic neuronal DNA degradation and programmed necrosis in rat via AIF[J]. Sci Rep, 2016, 6: 29362.
[15] Wang P, Shao BZ, Deng Z, et al. Autophagy in ischemic stroke[J]. Prog Neurobiol, 2018, 163-164: 98-117.
[16] Jung CH, Jun CB, Ro SH, et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery[J]. Mol Biol Cell, 2009, 20(7): 1992-2003.
[17] Yorimitsu T, Klionsky DJ. Autophagy: molecular machinery for self-eating[J]. Cell Death Differ, 2005, 12(Suppl 2): 1542-1552.
[18] Tanida I, Minematsu-Ikeguchi N, Ueno T, et al. Lysosomal turnover,but not a cellular level,of endogenous LC3 is a marker for autophagy[J]. Autophagy, 2005, 1(2): 84-91.
[19] Su J, Zhang T, Wang K, et al. Autophagy activation contributes to the neuroprotection of remote ischemic perconditioning against focal cerebral ischemia in rats[J]. Neurochem Res, 2014, 39(11): 2068-2077.
[20] Zhang DM, Zhang T, Wang MM, et al. TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury[J]. Free Radic Biol Med, 2019, 137: 13-23.
[21] Cui D, Wang L, Qi A, et al. Propofol prevents autophagic cell death following Oxygen and glucose deprivation in PC12 cells and cerebral ischemia-reperfusion injury in rats[J]. PLoS One, 2012, 7(4): e35324.
[22] Zhang X, Yan H, Yuan Y, et al. Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance[J]. Autophagy, 2013, 9(9): 1321-1333.
[23] Goodall ML, Fitzwalter BE, Zahedi S, et al. The autophagy machinery controls cell death switching between apoptosis and necroptosis[J]. Dev Cell, 2016, 37(4): 337-349.
[24] Itakura E, Mizushima N. p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding[J]. J Cell Biol, 2011, 192(1): 17-27.
[25] Suzuki K, Kubota Y, Sekito T, et al. Hierarchy of Atg proteins in pre-autophagosomal structure organization[J]. Genes Cells, 2007, 12(2): 209-218.
[26] Pietrzak M, Puzianowska-Kuznicka M. p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter[J]. Biol Chem, 2008, 389(4): 383-393.
[27] Yamada K, Yoshida K. Mechanical insights into the regulation of programmed cell death by p53 via mitochondria[J]. Biochim Biophys Acta Mol Cell Res, 2019, 1866(5): 839-848.
[28] Yonekawa T, Gamez G, Kim J, et al. RIP1 negatively regulates basal autophagic flux through TFEB to control sensitivity to apoptosis[J]. EMBO Rep, 2015, 16(6): 700-708.
[29] Cao M, Chen F, Xie N, et al. c-Jun n-terminal kinases differentially regulate TNF- and TLRs-mediated necroptosis through their kinase-dependent and -independent activities[J]. Cell Death Dis, 2018, 9(12): 1140.
[30] Wang P, Liang J, Li Y, et al. Down-regulation of miRNA-30a alleviates cerebral ischemic injury through enhancing beclin 1-mediated autophagy[J]. Neurochem Res, 2014, 39(7): 1279-1291.
[31] Wang X, Li R, Wang X, et al. Umbelliferone ameliorates cerebral ischemia-reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome[J]. Neurosci Lett, 2015, 600: 182-187.
[32] Li X, Cheng S, Hu H, et al. Progranulin protects against cerebral ischemia-reperfusion(I/R)injury by inhibiting necroptosis and oxidative stress[J]. Biochem Biophys Res Commun, 2020, 521(3): 569-576.
[33] Wang M, Li YJ, Ding Y, et al. Silibinin prevents autophagic cell death upon oxidative stress in cortical neurons and cerebral Ischemia-Reperfusion injury[J]. Mol Neurobiol, 2016, 53(2): 932-943.
[34] Xin Q, Ji B, Cheng B, et al. Endoplasmic reticulum stress in cerebral ischemia[J]. Neurochem Int, 2014, 68:18-27.
[35] Gao B, Zhang XY, Han R, et al. The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning[J]. Acta Pharmacol Sin, 2013, 34(5): 657-666.
[36] Degterev A, Huang ZH, Boyce M, et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury[J]. Nat Chem Biol, 2005, 1(2): 112-119.
[37] Yang R, Hu K, Chen J, et al. Necrostatin-1 protects hippocampal neurons against ischemia/reperfusion injury via the RIP3/DAXX signaling pathway in rats[J]. Neurosci Lett, 2017, 651: 207-215.
[38] Fakharnia F, Khodagholi F, Dargahi L, et al. Prevention of cyclophilin D-Mediated mPTP opening using Cyclosporine-A alleviates the elevation of necroptosis, autophagy and Apoptosis-Related markers following global cerebral Ischemia-Reperfusion[J]. J Mol Neurosci, 2017, 61(1): 52-60.
[39] Wang JY, Xia Q, Chu KT, et al. Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: a widely used inhibitor of autophagy[J]. J Neuropathol Exp Neurol, 2011, 70(4): 314-322.
[40] Xu Y, Wang J, Song X, et al. Protective mechanisms of CA074-me(other than cathepsin-B inhibition)against programmed necrosis induced by global cerebral ischemia/reperfusion injury in rats[J]. Brain Res Bull, 2016, 120: 97-105.
[41] Ryan F, Khodagholi F, Dargahi L, et al. Temporal pattern and crosstalk of necroptosis markers with autophagy and apoptosis associated proteins in ischemic hippocampus[J]. Neurotox Res, 2018, 34(1): 79-92.