参考文献/References:
[1] Wiseman FK, Al-Janabi T, Hardy J, et al. A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome[J]. Nat Rev Neurosci, 2015, 16(9): 564-574.
[2] Mann D, Davidson YS, Robinson AC, et al. Patterns and severity of vascular amyloid in Alzheimer's disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer's disease[J]. Acta Neuropathol, 2018, 136(4): 569-587.
[3] Guo Y, Wang Q, Chen S, et al. Functions of amyloid precursor protein in metabolic diseases[J]. Metabolism, 2021, 115: 154454.
[4] Galvão FJ, Grokoski KC, Da Silva BB, et al. The amyloid precursor protein(APP)processing as a biological Link between Alzheimer's disease and cancer[J]. Ageing Res Rev, 2019, 49: 83-91.
[5] Zhang YW, Thompson R, Zhang H, et al. APP processing in Alzheimer's disease[J]. Mol Brain, 2011, 4: 3.
[6] Castellani RJ, Plascencia-Villa G, Perry G. The amyloid cascade and Alzheimer's disease therapeutics: theory versus observation[J]. Lab Invest, 2019, 99(7): 958-970.
[7] Tiwari S, Atluri V, Kaushik A, et al. Alzheimer's disease: pathogenesis, diagnostics, and therapeutics[J]. Int J Nanomedicine, 2019, 14: 5541-5554.
[8] Selkoe DJ, Hardy J. The amyloid hypothesis of Alzheimer's disease at 25 years[J]. EMBO Mol Med, 2016, 8(6): 595-608.
[9] Zusso M, Barbierato M, Facci L, et al. Neuroepigenetics and alzheimer's disease: an update[J]. J Alzheimers Dis, 2018, 64(3): 671-688.
[10] Bertogliat MJ, Morris-Blanco KC, Vemuganti R. Epigenetic mechanisms of neurodegenerative diseases and acute brain injury[J]. Neurochem Int, 2020, 133:104642.
[11] Greenberg M, Bourc'his D. The diverse roles of DNA methylation in mammalian development and disease[J]. Nat Rev Mol Cell Biol, 2019, 20(10): 590-607.
[12] Lyko F. The DNA methyltransferase family: a versatile toolkit for epigenetic regulation[J]. Nat Rev Genet, 2018, 19(2): 81-92.
[13] Qazi TJ, Quan Z, Mir A, et al. Epigenetics in alzheimer's disease: perspective of DNA methylation[J]. Mol Neurobiol, 2018, 55(2): 1026-1044.
[14] Jones PA. Functions of DNA methylation: islands, start sites, gene bodies and beyond[J]. Nat Rev Genet, 2012, 13(7): 484-492.
[15] West RL, Lee JM, Maroun LE. Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient[J]. J Mol Neurosci, 1995, 6(2): 141-146.
[16] Tohgi H, Utsugisawa K, Nagane Y, et al. Reduction with age in methylcytosine in the promoter region-224 approximately-101 of the amyloid precursor protein gene in autopsy human cortex[J]. Brain Res Mol Brain Res, 1999, 70(2): 288-292.
[17] Lin HC, Hsieh HM, Chen YH, et al. S-Adenosylhomocysteine increases beta-amyloid formation in BV-2 microglial cells by increased expressions of beta-amyloid precursor protein and presenilin 1 and by hypomethylation of these gene promoters[J]. Neurotoxicology, 2009, 30(4): 622-627.
[18] Hou Y, Chen H, He Q, et al. Changes in methylation patterns of multiple genes from peripheral blood leucocytes of Alzheimer's disease patients[J]. Acta Neuropsychiatr, 2013, 25(2): 66-76.
[19] Barrachina M, Ferrer I. DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain[J]. J Neuropathol Exp Neurol, 2009, 68(8): 880-891.
[20] Wang SC, Oelze B, Schumacher A. Age-specific epigenetic drift in late-onset Alzheimer's disease[J]. PLoS One, 2008, 3(7): e2698.
[21] Chen KL, Wang SS, Yang YY, et al. The epigenetic effects of amyloid-beta(1-40)on global DNA and neprilysin genes in murine cerebral endothelial cells[J]. Biochem Biophys Res Commun, 2009, 378(1): 57-61.
[22] Liu H, Li W, Zhao S, et al. Folic acid attenuates the effects of amyloid β oligomers on DNA methylation in neuronal cells[J]. Eur J Nutr, 2016, 55(5): 1849-1862.
[23] Do CS, Hanzel CE, Jacobs ML, et al. Rescue of early bace-1 and global DNA demethylation by S-adenosylmethionine reduces amyloid pathology and improves cognition in an Alzheimer's model[J]. Sci Rep, 2016, 6: 34051.
[24] Karisetty BC, Bhatnagar A, Armour EM, et al. Amyloid-β peptide impact on synaptic function and neuroepigenetic gene control reveal new therapeutic strategies for alzheimer's disease[J]. Front Mol Neurosci, 2020, 13: 577622.
[25] Ledoux S, Nalbantoglu J, Cashman NR. Amyloid precursor protein gene expression in neural cell lines: influence of DNA cytosine methylation[J]. Brain Res Mol Brain Res, 1994, 24(1/4): 140-144.
[26] Morris-Blanco KC, Kim T, Lopez MS, et al. Induction of DNA hydroxymethylation protects the brain after stroke[J]. Stroke, 2019, 50(9): 2513-2521.
[27] Guo J, Su Y, Zhong C, et al. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain[J]. Cell, 2011, 145(3): 423-434.
[28] Martínez-Iglesias O, Carrera I, Carril JC, et al. DNA methylation in neurodegenerative and cerebrovascular disorders[J]. Int J Mol Sci, 2020, 21(6): 2220.
[29] Griñán-Ferré C, Sarroca S, Ivanova A, et al. Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice[J]. Aging(Albany NY), 2016, 8(4): 664-684.
[30] Huang Q, Xu S, Mo M, et al. Quantification of DNA methylation and hydroxymethylation in Alzheimer's disease mouse model using LC-MS/MS[J]. J Mass Spectrom, 2018, 53(7): 590-594.
[31] Shu LQ, Sun WJ, Li LP, et al. Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer's disease[J]. BMC Genomics, 2016, 17(1): 381.
[32] Jagust W. Imaging the evolution and pathophysiology of Alzheimer disease[J]. Nat Rev Neurosci, 2018, 19(11): 687-700.
[33] Nikolac PM, Videtic PA, Konjevod M, et al. Epigenetics of alzheimer's disease[J]. Biomolecules, 2021, 11(2): 195.
[34] Fransquet PD, Lacaze P, Saffery R, et al. DNA methylation analysis of candidate genes associated with dementia in peripheral blood[J]. Epigenomics, 2020, 12(23): 2109-2123.
[35] Roubroeks J, Smith RG, Van Den Hove D, et al. Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases[J]. J Neurochem, 2017, 143(2): 158-170.
[36] Poon CH, Tse L, Lim LW. DNA methylation in the pathology of Alzheimer's disease: from gene to cognition[J]. Ann N Y Acad Sci, 2020, 1475(1): 15-33.