参考文献/References:
[1] Feske SK. Ischemic stroke[J]. Am J Med, 2021, 134(12): 1457-1464.
[2] Li ZY, Song J, Zheng SL, et al. Adipocyte metrnl antagonizes insulin resistance through PPARγ signaling[J]. Diabetes, 2015, 64(12): 4011-4022.
[3] Miao ZW, Hu WJ, Li ZY, et al. Involvement of the secreted protein Metrnl in human diseases[J]. Acta Pharmacol Sin, 2020, 41(12): 1525-1530.
[4] El-Ashmawy HM, Selim F, Hosny T, et al. Association of low serum Meteorin like(Metrnl)concentrations with worsening of glucose tolerance, impaired endothelial function and atherosclerosis[J]. Diabetes Res Clin Pract, 2019, 150(5): 57-63.
[5] Schmid A, Karrasch T, Schäffler A. Meteorin-Like protein(metrnl)in obesity, during weight loss and in adipocyte differentiation[J]. J Clin Med, 2021, 10(19): 4338.
[6] Jørgensen JR, Fransson A, Fjord-Larsen L, et al. Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo[J]. Exp Neurol, 2012, 233(1): 172-181.
[7] Jørgensen JR, Thompson L, Fjord-Larsen L, et al. Characterization of meteorin--an evolutionary conserved neurotrophic factor[J]. J Mol Neurosci, 2009, 39(1/2): 104-116.
[8] Hu C, Zhang X, Song P, et al.Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway[Z],2020:101747.
[9] Li ZY, Zheng SL, Wang P, et al. Subfatin is a Novel Adipokine and Unlike Meteorin in Adipose and Brain Expression[J]. CNS Neurosci Ther, 2014, 20(4): 344-354.
[10] Rao RR, Long JZ, White JP, et al. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis[J]. Cell, 2014, 157(6): 1279-1291.
[11] Wang C, Pan Y, Song J, et al. Serum metrnl level is correlated with insulin resistance, but not with β-Cell function in type 2 diabetics[J]. Med Sci Monit, 2019, 25(6): 8968-8974.
[12] Zheng SL, Li ZY, Song J, et al. Metrnl: a secreted protein with new emerging functions[J]. Acta Pharmacol Sin, 2016, 37(5): 571-579.
[13] Nishino J, Yamashita K, Hashiguchi H, et al. Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension[J]. EMBO J, 2004, 23(9): 1998-2008.
[14] Ramialison M, Bajoghli B, Aghaallaei N, et al. Rapid identification of PAX2/5/8 direct downstream targets in the otic vesicle by combinatorial use of bioinformatics tools[J]. Genome Biol, 2008, 9(10): R145.
[15] 张敏,丁瑞麟,江凤,等.循环Metrnl与糖尿病心肌病的关系及相关分子机制[J].海南医学院学报,2022(9):663-668.
[16] Ushach I, Burkhardt AM, Martinez C, et al. METEORIN-LIKE is a cytokine associated with barrier tissues and alternatively activated macrophages[J]. Clin Immunol, 2015, 156(2): 119-127.
[17] Huang R, Balu AR, Molitoris KH, et al.The role of Meteorin-like in skeletal development and bone fracture healing[Z],2022.
[18] Fotis L, Giannakopoulos D, Stamogiannou L, et al. Intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 in children[J]. Do they play a role in the progression of atherosclerosis.Hormones(Athens), 2012, 11(2): 140-146.
[19] Libby P. Inflammation in atherosclerosis[J]. Arterioscler Thromb Vasc Biol, 2012, 32(9): 2045-2051.
[20] Geovanini GR, Libby P. Atherosclerosis and inflammation: overview and updates[J]. Clin Sci(Lond), 2018, 132(12): 1243-1252.
[21] Castaneda AB, Petty LE, Scholz M, et al. Associations of carotid intima media thickness with gene expression in whole blood and genetically predicted gene expression across 48 tissues[J]. Hum Mol Genet, 2022, 31(7): 1171-1182.
[22] Stein JH, Korcarz CE, Hurst RT, et al. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk:a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force[J]. Endorsed by the Society for Vascular Medicine.J Am Soc Echocardiogr, 2008, 21(2): 93-111.
[23] Stein JH, Korcarz CE, Post WS. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: summary and discussion of the American Society of Echocardiography consensus statement[J]. Prev Cardiol, 2009, 12(1): 34-38.
[24] 郑斯莉. Metrnl对血管张力及动脉粥样硬化的影响及机制研究[J].2018,32(1):R139.
[25] Qi Q, Hu WJ, Zheng SL, et al. Metrnl deficiency decreases blood HDL cholesterol and increases blood triglyceride[J]. Acta Pharmacol Sin, 2020, 41(12): 1568-1575.
[26] Wang K, Li F, Wang C, et al. Serum levels of Meteorin-Like(metrnl)are increased in patients with newly diagnosed type 2 diabetes mellitus and are associated with insulin resistance[J]. Med Sci Monit, 2019, 25(9): 2337-2343.
[27] Jung TW, Lee SH, Kim HC, et al. METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARδ-dependent pathways in skeletal muscle of mice[J]. Exp Mol Med, 2018, 50(9): 1-11.
[28] Liu ZX, Ji HH, Yao MP, et al. Serum metrnl is associated with the presence and severity of coronary artery disease[J]. J Cell Mol Med, 2019, 23(1): 271-280.
[29] Dadmanesh M, Aghajani H, Fadaei R, et al. Lower serum levels of Meteorin-like/Subfatin in patients with coronary artery disease and type 2 diabetes mellitus are negatively associated with insulin resistance and inflammatory cytokines[J]. PLoS One, 2018, 13(9): e0204180.
[30] Maida CD, Norrito RL, Daidone M, et al. Neuroinflammatory mechanisms in ischemic stroke: focus on cardioembolic stroke, background, and therapeutic approaches[J]. Int J Mol Sci, 2020, 21(18): 6454.
[31] Zhang XG, Xue J, Yang WH, et al. Inflammatory markers as Independent predictors for stroke outcomes[J]. Brain Behav, 2021, 11(1): e01922.
[32] Moskowitz MA, Lo EH, Iadecola C. The science of stroke: mechanisms in search of treatments[J]. Neuron, 2010, 67(2): 181-198.
[33] Hu X, Li P, Guo Y, et al. Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia[J]. Stroke, 2012, 43(11): 3063-3070.
[34] Yang S, Yuan HQ, Hao YM, et al. Macrophage polarization in atherosclerosis[J]. Clin Chim Acta, 2020, 501(3): 142-146.
[35] Nair MG, Guild KJ, Artis D. Novel effector molecules in type 2 inflammation: lessons drawn from helminth infection and allergy[J]. J Immunol, 2006, 177(3): 1393-1399.
[36] Cekanaviciute E, Buckwalter MS. Astrocytes: integrative regulators of neuroinflammation in stroke and other neurological diseases[J]. Neurotherapeutics, 2016, 13(4): 685-701.
[37] Lin JT, Kakkar V, Lu XJ. Essential roles of Toll-Like receptors in atherosclerosis[J]. Curr Med Chem, 2016, 23(5): 431-454.
[38] Zhang BB, Zhou G, Li C. AMPK: an emerging drug target for diabetes and the metabolic syndrome[J]. Cell Metab, 2009, 9(5): 407-416.
[39] Hardie DG, Schaffer BE, Brunet A. AMPK: an Energy-Sensing pathway with multiple inputs and outputs[J]. Trends Cell Biol, 2016, 26(3): 190-201.
[40] Shuai J, Tian L, Ji T, et al. AMPK: potential therapeutic target for ischemic stroke[J]. Theranostics, 2018, 8(16): 4535-4551.
[41] Deng J, Lu PD, Zhang Y, et al. Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2[J]. Mol Cell Biol, 2004, 24(23): 10161-10168.
[42] Qiu J, Wang M, Zhang J, et al. The neuroprotection of Sinomenine against ischemic stroke in mice by suppressing NLRP3 inflammasome via AMPK signaling[J]. Int Immunopharmacol, 2016, 40(9): 492-500.
[43] 刘伟,唐蓉,张晶玉,等.AMPK在缺血性脑卒中中的研究进展[J].中国康复理论与实践,2020,26(12):1422-1426.
[44] Yang Y, Zhang XJ, Li LT, et al. Apelin-13 protects against apoptosis by activating AMP-activated protein kinase pathway in ischemia stroke[J]. Peptides, 2016, 75(12): 96-100.
[45] Jung TW, Pyun DH, Kim TJ, et al. Meteorin-like protein(METRNL)/IL-41 improves LPS-induced inflammatory responses via AMPK or PPARδ-mediated signaling pathways[J]. Adv Med Sci, 2021, 66(1): 155-161.
[46] Turnley AM, Stapleton D, Mann RJ, et al. Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system[J]. J Neurochem, 1999, 72(4): 1707-1716.
[47] Gadalla AE, Pearson T, Currie AJ, et al. AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus[J]. J Neurochem, 2004, 88(5): 1272-1282.
[48] 李则衡,崔桂云,孙洁,等.急性脑梗死患者血清流星素和白介素6的相关性研究[J].中风与神经疾病杂志,2021,38(10):1060-1064.